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1

Nonenzymatic reduction of brucine N-oxide by the heme group of cytochrome P450

Koji Takekawa, Kazumi Sugihara, Shigeyuki Kitamura, Kiyoshi Tatsumi

Journal:

Year:

1997

Language:

english

File:

PDF, 246 KB

english, 1997

2

Metabolic Activation of the Proestrogens trans-Stilbene and trans-Stilbene Oxide by Rat Liver Microsomes

Kazumi Sugihara, Shigeyuki Kitamura, Seigo Sanoh, Shigeru Ohta, Nariaki Fujimoto, Satoshi Maruyama, Akihiro Ito

Journal:

Toxicology and Applied Pharmacology

Year:

2000

Language:

english

File:

PDF, 152 KB

english, 2000

3

1P-0159 Amlodipine and fluvastatin ameliorate the accumulation of advanced glycation end products in atherogenic rabbit

Nakajima, Y., Okajima, F., Ono, C., Tanimura, K., Sugihara, H., Amano, M., Kazumi, A., Hashimoto, T., Oikawa, S.

Journal:

Atherosclerosis Supplements

Year:

2003

Language:

english

File:

PDF, 65 KB

english, 2003

4

Structure–activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity

Shimizu, Ryo, Yamaguchi, Masafumi, Uramaru, Naoto, Kuroki, Hiroaki, Ohta, Shigeru, Kitamura, Shigeyuki, Sugihara, Kazumi

Journal:

Year:

2013

Language:

english

File:

PDF, 2.09 MB

english, 2013

5

Hydrolytic metabolism of phenyl and benzyl salicylates, fragrances and flavoring agents in foods, by microsomes of rat and human tissues

Ozaki, Hitomi, Sugihara, Kazumi, Tamura, Yuki, Fujino, Chieri, Watanabe, Yoko, Uramaru, Naoto, Sone, Tomomichi, Ohta, Shigeru, Kitamura, Shigeyuki

Journal:

Food and Chemical Toxicology

Year:

2015

Language:

english

File:

PDF, 696 KB

english, 2015

6

Synthesis of hydrophobic phase-tagged prolyl peptides featuring rapid reaction/separation

Kazuhiro Chiba, Mari Sugihara, Kazumi Yoshida, Yuzuru Mikami, Shokaku Kim

Journal:

Year:

2009

Language:

english

File:

PDF, 349 KB

english, 2009

7

Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture

Shigeyuki Kitamura, Norimasa Jinno, Tomoharu Suzuki, Kazumi Sugihara, Shigeru Ohta, Hiroaki Kuroki, Nariaki Fujimoto

Journal:

Year:

2005

Language:

english

File:

PDF, 409 KB

english, 2005

8

The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats

Yuri Nakamura, Kazumi Sugihara, Tomomichi Sone, Masakazu Isobe, Shigeru Ohta, Shigeyuki Kitamura

Journal:

Year:

2007

Language:

english

File:

PDF, 529 KB

english, 2007

9

Synthesis and characterization of 3,4-dl-t-butylfuran, pyrrole, and selenophene

Juzo Nakayama, Yoshiaki Sugihara, Kazumi Terada, Edward L. Clennan

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 268 KB

english, 1990

10

Comparative study of aryl hydrocarbon receptor ligand activities of six chemicals in vitro and in vivo

Kazumi Sugihara, Takashige Okayama, Shigeyuki Kitamura, Keisuke Yamashita, Mineo Yasuda, Shinichi Miyairi, Yasushi Minobe, Shigeru Ohta

Journal:

Archives of Toxicology

Year:

2008

Language:

english

File:

PDF, 455 KB

english, 2008

11

S-(-)-nicotine-1′-N-oxide reductase activity of rat liver aldehyde oxidase

Kazumi Sugihara, Shigeyuki Kitamura, Kiyoshi Tatsumi

Journal:

Year:

1996

Language:

english

File:

PDF, 317 KB

english, 1996

12

Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver

Kazumi Sugihara, Shigeyuki Kitamura, Kiyoshi Tatsumi, Toshimasa Asahara, Kiyohiko Dohi

Journal:

Year:

1997

Language:

english

File:

PDF, 368 KB

english, 1997

13

Reductive dechlorination of DDT to DDD by rat blood

Kazumi Sugihara, Shigeyuki Kitamura, Shigeru Ohta

Journal:

Year:

1998

Language:

english

File:

PDF, 298 KB

english, 1998

14

Variation of Hepatic Methotrexate 7-Hydroxylase Activity in Animals and Humans

Shigeyuki Kitamura, Kazumi Sugihara, Keiko Nakatani, Shigeru Ohta, Toshinari Oh-Hara, Shin-Ichi Ninomiya, Carol E. Green, Charles A. Tyson

Journal:

Year:

1999

Language:

english

File:

PDF, 177 KB

english, 1999

15

Debromination of (α-Bromoiso-valeryl)urea Catalysed by Rat Blood

Shigeyuki Kitamura, Mie Kuwasako, Kazumi Sugihara, Kiyoshi Tatsumi, Shigeru Ohta

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 112 KB

english, 1999

16

Presence or absence of a gallate moiety on catechins affects their cellular transport

Masaaki Kadowaki, Narumi Sugihara, Tomohiko Tagashira, Kazumi Terao, Koji Furuno

Journal:

Journal of Pharmacy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 483 KB

english, 2008

17

Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens

Tomoharu Suzuki, Shigeyuki Kitamura, Ryuki Khota, Kazumi Sugihara, Nariaki Fujimoto, Shigeru Ohta

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 659 KB

english, 2005

18

Aryl Hydrocarbon Receptor (AhR)-Mediated Induction of Xanthine Oxidase/Xanthine Dehydrogenase Activity by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Kazumi Sugihara, Shigeyuki Kitamura, Tuyoshi Yamada, Shigeru Ohta, Keisuke Yamashita, Mineo Yasuda, Yoshiaki Fujii-Kuriyama

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 166 KB

english, 2001

19

Participation of liver aldehyde oxidase in reductive metabolism of hydroxamic acids to amides

Kazumi Sugihara, Kiyoshi Tatsumi

Journal:

Archives of Biochemistry and Biophysics

Year:

1986

Language:

english

File:

PDF, 366 KB

english, 1986

20

Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo

Kazumi Sugihara, Shigeyuki Kitamura, Tsuyoshi Yamada, Takashige Okayama, Shigeru Ohta, Keisuke Yamashita, Mineo Yasuda, Yoshiaki Fujii-Kuriyama, Ken'ich Saeki, Saburo Matsui, Tomonari Matsuda

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 375 KB

english, 2004

21

Production of superoxide radical in reductive metabolism of a synthetic food-coloring agent, indigocarmine, and related compounds

Yoichi Kohno, Shigeyuki Kitamura, Tsuyoshi Yamada, Kazumi Sugihara, Shigeru Ohta

Journal:

Year:

2005

Language:

english

File:

PDF, 229 KB

english, 2005

22

Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: A comparative approach

Narumi Sugihara, Kumiko Toyama, Tastuaki Okamoto, Masaaki Kadowaki, Kazumi Terao, Koji Furuno

Journal:

Toxicology in Vitro

Year:

2007

Language:

english

File:

PDF, 637 KB

english, 2007

23

An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide

Kana Matsubara, Seigo Sanoh, Shigeru Ohta, Shigeyuki Kitamura, Kazumi Sugihara, Nariaki Fujimoto

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 390 KB

english, 2012

24

Estrogenic activity of an environmental pollutant, 2-nitrofluorene, after metabolic activation by rat liver microsomes

Takashi Fujimoto, Shigeyuki Kitamura, Seigo Sanoh, Kazumi Sugihara, Shin’ichi Yoshihara, Nariaki Fujimoto, Shigeru Ohta

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 280 KB

english, 2003

25

Cynomolgus monkey liver aldehyde oxidase: extremely high oxidase activity and an attempt at purification

Kazumi Sugihara, Yasuko Katsuma, Shigeyuki Kitamura, Shigeru Ohta, Morioki Fujitani, Hideaki Shintani

Journal:

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology

Year:

2000

Language:

english

File:

PDF, 181 KB

english, 2000

26

Strain differences of the ability to hydroxylate methotrexate in rats

Shigeyuki Kitamura, Keiko Nakatani, Kazumi Sugihara, Shigeru Ohta

Journal:

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

27

The Role of Mammalian Intestinal Bacteria in the Reductive Metabolism of Zonisamide

SHIGEYUKI KITAMURA, KAZUMI SUGIHARA, MIE KUWASAKO, KIYOSHI TATSUMI

Journal:

Journal of Pharmacy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 374 KB

english, 1997

28

Ultraviolet-photoproduct of acetaminophen: Structure determination and evaluation of ecotoxicological effect

Kawabata, Kohei, Sugihara, Kazumi, Sanoh, Seigo, Kitamura, Shigeyuki, Ohta, Shigeru

Journal:

Journal of Photochemistry and Photobiology A: Chemistry

Year:

2012

Language:

english

File:

PDF, 548 KB

english, 2012

29

Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues

Ozaki, Hitomi, Sugihara, Kazumi, Watanabe, Yoko, Fujino, Chieri, Uramaru, Naoto, Sone, Tomomichi, Ohta, Shigeru, Kitamura, Shigeyuki

Journal:

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

30

Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes

Tanoue, Chiaki, Sugihara, Kazumi, Uramaru, Naoto, Tayama, Yoshitaka, Watanabe, Yoko, Horie, Toru, Ohta, Shigeru, Kitamura, Shigeyuki

Journal:

Year:

2013

Language:

english

File:

PDF, 350 KB

english, 2013

31

2,5-Dihydroxy-4-methoxybenzophenone: a novel major in vitro metabolite of benzophenone-3 formed by rat and human liver microsomes

Kamikyouden, Nagisa, Sugihara, Kazumi, Watanabe, Yoko, Uramaru, Naoto, Murahashi, Tsuyoshi, Kuroyanagi, Masanori, Sanoh, Seigo, Ohta, Shigeru, Kitamura, Shigeyuki

Journal:

Year:

2013

Language:

english

File:

PDF, 758 KB

english, 2013

32

In vitro metabolism of cis- and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities

Tange, Satoko, Fujimoto, Nariaki, Uramaru, Naoto, Sugihara, Kazumi, Ohta, Shigeru, Kitamura, Shigeyuki

Journal:

Environmental Toxicology and Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

33

Balloon-Occluded Retrograde Transvenous Obliteration (BRTO) for a Direct Shunt between the Inferior Mesenteric Vein and the Inferior Vena Cava in a Patient with Hepatic Encephalopathy

Ibukuro, Kenji, Sugihara, Toru, Tanaka, Rei, Fukuda, Hozumi, Abe, Shoko, Tobe, Kimiko, Tateishi, Ryosuke, Tagawa, Kazumi

Journal:

Journal of Vascular and Interventional Radiology

Year:

2007

Language:

english

File:

PDF, 741 KB

english, 2007

34

Nuclear Hormone Receptor Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells

Hiroyuki Kojima, Shinji Takeuchi, Naoto Uramaru, Kazumi Sugihara, Takahiko Yoshida and Shigeyuki Kitamura

Journal:

Environmental Health Perspectives

Year:

2009

Language:

english

File:

PDF, 3.37 MB

english, 2009

35

Estrogenic Activity of Styrene Oligomers after Metabolic Activation by Rat Liver Microsomes

Shigeyuki Kitamura, Motoko Ohmegi, Seigo Sanoh, Kazumi Sugihara, Shin'ichi Yoshihara, Nariaki Fujimoto and Shigeru Ohta

Journal:

Environmental Health Perspectives

Year:

2003

Language:

english

File:

PDF, 1.90 MB

english, 2003

36

Effects of Polybrominated Diphenyl Ethers (PBDEs) and Their Derivatives on Protein Disulfide Isomerase Activity and Growth Hormone Release of GH3 Cells

Hashimoto, Shoko, Yoshimura, Hiromi, Okada, Kazushi, Uramaru, Naoto, Sugihara, Kazumi, Kitamura, Shigeyuki, Imaoka, Susumu

Journal:

Chemical Research in Toxicology

Year:

2012

Language:

english

File:

PDF, 1.89 MB

english, 2012

37

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

Kitamura, Shigeyuki, Sugihara, Kazumi

Journal:

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

38

Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

Sanoh, Seigo, Tayama, Yoshitaka, Sugihara, Kazumi, Kitamura, Shigeyuki, Ohta, Shigeru

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

39

Metabolism of UV-filter benzophenone-3 by rat and human liver microsomes and its effect on endocrine-disrupting activity

Watanabe, Yoko, Kojima, Hiroyuki, Takeuchi, Shinji, Uramaru, Naoto, Sanoh, Seigo, Sugihara, Kazumi, Kitamura, Shigeyuki, Ohta, Shigeru

Journal:

Toxicology and Applied Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

40

Estrogenic Activity of Styrene Oligomers after Metabolic Activation by Rat Liver Microsomes

Kitamura, Shigeyuki, Ohmegi, Motoko, Sanoh, Seigo, Sugihara, Kazumi, Yoshihara, Shinichi, Fujimoto, Nariaki, Ohta, Shigeru

Journal:

Environmental Health Perspectives

Year:

2002

Language:

english

File:

PDF, 274 KB

english, 2002

41

Variation of Hepatic Methotrexate 7-Hydroxylase Activity in Animals and Humans

Kitamura, Shigeyuki, Sugihara, Kazumi, Nakatani, Keiko, Ohta, Shigeru, Oh-Hara, Toshinari, Ninomiya, Shin-Ichi, Green, Carol E., Tyson, Charles A.

Journal:

Year:

1999

Language:

english

File:

PDF, 173 KB

english, 1999

42

Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

Sanoh, Seigo, Naritomi, Yoichi, Fujimoto, Mami, Sato, Koya, Kawamura, Akio, Horiguchi, Aya, Sugihara, Kazumi, Kotake, Yaichiro, Ohshita, Hiroki, Tateno, Chise, Horie, Toru, Kitamura, Shigeyuki, Ohta,

Journal:

Year:

2015

Language:

english

File:

PDF, 464 KB

english, 2015

43

Nuclear Hormone Receptor Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells

Kojima, Hiroyuki, Takeuchi, Shinji, Uramaru, Naoto, Sugihara, Kazumi, Yoshida, Takahiko, Kitamura, Shigeyuki

Journal:

Environmental Health Perspectives

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

44

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

Inoue, Tae, Sugihara, Kazumi, Ohshita, Hiroki, Horie, Toru, Kitamura, Shigeyuki, Ohta, Shigeru

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2009

Language:

english

File:

PDF, 539 KB

english, 2009

45

Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver

Nurrochmad, Arief, Ishii, Yuji, Nakanoh, Hitomi, Inoue, Tae, Horie, Toru, Sugihara, Kazumi, Ohta, Shigeru, Taketomi, Akinobu, Maehara, Yoshihiko, Yamada, Hideyuki

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

46

In vitro metabolism of methiocarb and carbaryl in rats, and its effect on their estrogenic and antiandrogenic activities

Tange, Satoko, Fujimoto, Nariaki, Uramaru, Naoto, Wong, Fung Fuh, Sugihara, Kazumi, Ohta, Shigeru, Kitamura, Shigeyuki

Journal:

Environmental Toxicology and Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.56 MB

english, 2016

47

Drug-Metabolizing Ability of Molybdenum Hydroxylases

Kitamura, Shigeyuki, Sugihara, Kazumi, Ohta, Shigeru

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2006

Language:

english

File:

PDF, 276 KB

english, 2006

48

Purification and Some Properties of Hamster Liver Aldehyde Oxidase.

SUGIHARA, Kazumi, KATSUMA, Yasuko, TANAKA, Chikage, KITAMURA, Shigeyuki

Journal:

Biological & Pharmaceutical Bulletin

Year:

1999

File:

PDF, 551 KB

1999

49

Conversion of Dieldrin to Aldrin by Intestinal Bacteria in Rats.

KITAMURA, Shigeyuki, MITA, Masashi, SHIMIZU, Yuri, SUGIHARA, Kazumi, OHTA, Shigeru

Journal:

Biological & Pharmaceutical Bulletin

Year:

1999

File:

PDF, 531 KB

1999

50

Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver.

KITAMURA, Shigeyuki, NAKATANI, Keiko, OHASHI, Koji, SUGIHARA, Kazumi, HOSOKAWA, Ryuji, AKAGAWA, Yasumasa, OHTA, Shigeru

Journal:

Biological & Pharmaceutical Bulletin

Year:

2001

Language:

english

File:

PDF, 69 KB

english, 2001

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